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What are some of the effects of antenatal steroids on the mother?

    A rise in the white blood count (WBC) may occur as early as two hours after the first injection of betamethasone.

      The mean WBC increases by about 30% within 24 hours.
      The WBC count generally returns to baseline three days after the first betamethasone or dexamethasone injection .

    Hyperglycemia may also occur as early as 3 to 8 hours after antenatal steroids have been given. Glucose values return to normal 24 hours after the second dose in nondiabetic patients, but may remain elevated for up to 5 days after the first dose in diabetic patients

    Transient improvement in blood pressure control, increased urinary output, decreased AST, and increased platelet count has been seen in patients with HELLP syndrome treated with corticosteroids (dexamethasone more so than betamethasone) .

REFERENCES

1. Danesh A, et. al., .Effects of antenatal corticosteroids on maternal serum indicators of infection in women at risk for preterm delivery: A randomized trial comparing betamethasone and dexamethasone.J Res Med Sci. 2012 Oct;17(10):911-7.PMID:23825988
2. Vaisbuch E, et al., The effect of betamethasone administration to pregnant women on maternal serum indicators of infection.J Perinat Med. 2002;30(4):287-91. PMID:12235715
3. Kadanali S,et. al., Changes in leukocyte, granulocyte and lymphocyte counts following antenatal betamethasone administration to pregnant women.Int J Gynaecol Obstet. 1997 Sep;58(3):269-74. PMID:9286859
4. Wallace EM, et al. Haematological effects of betamethasone treatment in late pregnancy.Aust N Z J Obstet Gynaecol. 1998 Nov;38(4):396-8. PMID:9890217
5. Star J, Hogan J, Sosa ME, Carpenter MW. Glucocorticoid-associated maternal hyperglycemia: a randomized trial of insulin prophylaxis. J Matern Fetal Med. 2000 Sep-Oct;9(5):273-7.PMID:11132581
And may remain elevated for up to 5 days after
6. Mathiesen ER, et. al., Insulin dose during glucocorticoid treatment for fetal lung maturation in diabetic pregnancy: test of an algorithm [correction of analgoritm]. Acta Obstet Gynecol Scand. 2002 Sep;81(9):835-9.PMID:12225298
7. Kalra S, Kalra B, Gupta Y. Glycemic management after antenatal corticosteroid therapy. N Am J Med Sci. 2014 Feb;6(2):71-6. doi: 10.4103/1947-2714.127744. PMID:24696828
8. Isler CM, et. al., A prospective, randomized trial comparing the efficacy of dexamethasone and betamethasone for the treatment of antepartum HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome.Am J Obstet Gynecol. 2001 Jun;184(7):1332-7; PMID:11408849
9 Isler C, et. al., Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum HELLP syndrome.Int J Gynaecol Obstet. 2003 Mar;80(3):291-7. PMID:12628531
 

  

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