First Trimester of Pregnancy [4]
( Less than14 weeks 0 days)
|
Weeks 1 and 2 of Pregnancy |
|
During the first two weeks
after the last menstrual period egg follicles mature in
the ovaries
under the stimulus of follicle-stimulating hormone (FSH) a
hormone secreted by the pituitary gland in the brain. High
levels of the hormone estradiol, produced by the developing
egg follicle, cause secretion of luteinizing hormone (LH)
,yet another hormone from the pituitary gland. LH causes
release of the egg from its follicle (ovulation) For women with 28-day cycles, ovulation usually
occurs on days 13 to 15. |
Gestational Age 3 weeks . Embryonic Age 1 week . |
|
- During the third week, if fertilization occurs , the
fertilized egg (called a zygote) will begin producing the
hormone human chorionic gonadotropin (the pregnancy hormone)
- Human chorionic gonadotropin first becomes detectable in
the mother's blood and urine between 6 and 14 days after
fertilization (3 to 4 weeks gestational age).
- During the 3rd week the sex of the fetus is determined
by the father's sperm,
and twins may be formed.
- Fatigue and swollen or tender breasts are sometimes the
first signs of pregnancy.
|
Gestational Age 4 weeks
( 0.9 months) .
Embryonic Age 2 weeks |
|
The embryo
is the size of a pinhead.
Most pregnancy tests will be positive at this time . |
Gestational Age 5
weeks
(1.2 months) .
Embryonic Age 3 weeks |
|
- The brain, spine, and heart have begun to form. By
the end of the week the heart will be pumping blood.
- Week 5 is the beginning of the embryonic period which
lasts from the the 5th to the 10th week.
- It is during this critical period that many birth
defects occur in the developing embryo.
- Most of these birth defects will have no known cause or
be due to a combination of factors (multifactorial).
|
Gestational Age 6
weeks
(1.4 months) .
Embryonic Age 4 weeks |
|
- The
embryo is now about the
size of a pea.
- The average
crown to rump length is about 0.2 inches ( 0.5 cm)
- The eyes,
nostrils , and arms are taking shape.
- The heart is
beating at about 110 beats per minute and sometimes may be
seen using a transvaginal ultrasound at this time.
|
Gestational Age 7
weeks (1.6 months)
.
Embryonic Age 5 weeks |
|
- The embryo is now about 0.
37
inches (0.95cm ) long
- This week the hands and feet
are forming as well as the mouth and face.
- The heart
is beating at about 120 beats per minute. Movement of the embryo
can be detected by ultrasound.
-
By week 7 the trachea and bronchi of the lungs have formed ,
and the pseudoglandular stage of lung development
begins [17]
-
Crown–rump length of 7 mm or greater and no heartbeat, or
mean sac diameter of 25 mm or greater and no embryo is
considered consistent with early pregnancy loss [20]
|
Gestational Age 8
weeks (1.8
months)
.
Embryonic Age 6 weeks |
|
The average embryo
at 8 weeks
is 0.6 inches (1.6 cm) long
- The embryo is about the size of
a bean. The fingers and toes are developing.
-
In a process is called physiological gut herniation , the intestine elongates and moves
outside of the abdomen herniating into the base of
the umbilical cord and rotate counter-clockwise at about 8 weeks . The intestine returns into the fetal abdomen by about 12 weeks
[18] .
|
Gestational Age 9
weeks (2.1
months)
.
Embryonic Age 7 weeks |
|
- The heart is
beating at about 170 beats per minute.
-
The average embryo
at 9 weeks is 0.9 inches (2.3 cm) long
|
Gestational Age 10
weeks
(2.3 months)
.
Fetal Age
8 weeks |
|
- The embryo's
tail has disappeared and it is now called a fetus. Fingerprints
are being formed [11], and bone cells are replacing cartilage.
-
The average fetus at
10 weeks is
1.22 inches (3.1 cm) long and weighs 1.2 ounces (35
grams) .
|
Gestational Age 11
weeks
(2.5 months)
.
Fetal Age 9 weeks |
|
- The fetus
is starting to have breathing movements . It can open its mouth and swallow.
-
The average fetus at
11 weeks is
1.6 inches (4.1 cm) long and weighs 1.6 ounces (45
grams) .
|
Gestational Age 12
weeks (2.8
months)
.
Fetal Age 10 weeks |
|
- The fetus is starting to make
random movements .
- The fetus begins to
concentrate iodine in its thyroid and produce thyroid
hormone at about this time.
- The pancreas is beginning to
make insulin, and the kidneys are producing urine. The heart beat can usually
be heard with and
electronic monitor at this time.
-
The average fetus at
12 weeks is
2.1 inches (5.4 cm) long and weighs 2.1 ounces (58
grams) .
|
Gestational Age 13
weeks (3 months)
.
Fetal Age 12 weeks |
|
The average fetus at
13 weeks is
2.6 inches (6.7 cm) long and weighs 2.6 ounces (73
grams) .
- All major organs are formed
now, but they are too immature for the fetus to survive out of
the womb.
-
Physiological gut herniation should be complete by this time
-
The fetal bladder can be consistently seen using ultrasound after 13
weeks [24].
|
Second Trimester of Pregnancy
(14 weeks and 0 days through 27 weeks and 6 days)
|
Gestational Age 14
weeks (3.2
months)
.
Fetal Age 12 weeks |
|
- The
fetus's toenails are
appearing . The gender may sometimes be seen
-
The average fetus at
14 weeks is 5.8 inches (14.7 cm) long (crown t
to heel) and weighs 3.3 ounces (93
grams) .
|
Gestational Age 15
weeks (3.5
months)
.
Fetal Age 13 weeks |
|
- Fetal movement may be sensed now (called quickening). Some
mothers don't feel the fetus moving until about 25
weeks.
-
The average fetus at
15 weeks is 6.6 inches (16.7 cm) long and weighs 4.1
ounces (117
grams) .
|
Gestational Age 16 to 17
weeks (3.7
to 3.9 months)
.
Fetal Age 14 to 15 weeks |
|
The average 16
week fetus is 7.3 inches (18.6cm) long and weighs
5.2 ounces (146
grams) .
- Hearing is
beginning to form [12].
- The canalicular period of lung development has
started and will continue until 25 weeks [17]
The average 17 week
fetus is 8 inches (20.4 cm) long and weighs 6.4
ounces (181
grams) .
- The pseudoglandular stage of lung development ends at about 17 weeks
. There are still NO ALVEOLI (the air sacs in the lungs where the exchange of oxygen and carbon dioxide occurs), so respiration is not possible at this time
[17].
|
Gestational Age 18
weeks
(4.1 months)
.
Fetal Age 16 weeks |
|
- The ears are standing out, and
the fetus is beginning to respond to sound.
-
The average 18 week fetus is
8.7 inches (22.2 cm) long and weighs 7.9 ounces (223
grams) .
-
The cerebellar vermis can be demonstrated to be fully formed on
ultrasound [22].
|
Gestational Age 19
weeks (4.4
months)
.
Fetal Age 17 weeks |
|
- The ears, nose and lips are
now recognizable.
-
The average fetus at
19 weeks is 9.5 inches (24 cm) long and weighs
9.6 ounces (273
grams) .
|
Gestational Age 20
weeks (4.6
months)
.
Fetal Age 18 weeks |
|
- The fetus is covered in fine
hair (called lanugo) , has some scalp hair, and is capable of producing IgG and IgM ( two types of antibodies)
-
The average fetus at
20 weeks is 10.1 inches (25.7 cm) long and weighs
11.7 ounces (331
grams) .
|
Gestational Age 21
weeks (4.8
months)
.
Fetal Age 19 weeks |
|
- The fetus is now able to suck
and grasp, and may have bouts of hiccups. Some women may begin
feeling Braxton Hicks contractions at this time.
-
The average fetus at
21 weeks is 10.8 inches (27.4 cm) long and
weighs 14.1 ounces (399
grams) .
|
Gestational Age 22
weeks (5.1 months)
.
Fetal Age 20 weeks |
|
-
The average fetus at
22 weeks is 11.4 inches (29 cm)
long and weighs 1.1 pound (478
grams) .
-
Survival and morbidity
|
Gestational Age 23
weeks (5.3
months)
.
Fetal Age 21 weeks |
|
- The fetus is having rapid eye
movements during sleep.
-
The average fetus at
23 weeks is 12.1 inches (30.6 cm)
long and weighs 1.3 pounds (568
grams) .
-
The entire corpus callosum may not be be seen using transabdominal ultrasound
before this age [23].
-
Survival and morbidity
|
Gestational Age 24 weeks
(5.5 months)
.
Fetal Age 22 weeks |
|
-
The average fetus at
24 weeks is 12.7 inches (32.2 cm) long
and weighs 1.5 pounds (670
grams) .
-
The terminal saccular stage of lung development
has started [17]
-
Survival and morbidity
|
Gestational Age 25
weeks (5.8 months)
.
Fetal Age 23 weeks |
|
-
The average fetus at
25 weeks is 13.3 inches (33.7 cm)
long and weighs 1.7 pounds (785
grams) .
- The
canalicular period of lung development is ending. Respiration is possible towards
the end of this period [17,19]
-
Survival and morbidity
|
Gestational Age 26 weeks (6
months)
.
Fetal Age 24 weeks |
|
- The fetus can respond to
sounds that occur in the mother's surroundings. It's eyelids can open
and close
-
The average fetus at
26 weeks is 13.8 inches (35.1 cm)
long and weighs 2 pounds (913
grams) .
-
Survival out of the womb at this age would be expected to be
~87[21]
|
Gestational Age 27
weeks (6.2 months)
.
Fetal Age 25 weeks |
|
-
The average fetus at
27 weeks is 14.4 inches (36.6 cm)
long and weighs 2.3 pounds (1055
grams) .
-
Survival out of the womb at this age would be expected to be
~94%.[21]
|
Third Trimester of Pregnancy
(28 weeks 0 days through delivery)
|
Gestational Age 28 weeks (6.4 months)
.
Fetal Age 26 weeks |
|
The
fetus has eyelashes and
it's skin is red and covered with vernix caseosa a waxy
substance that is believed to act as a protective film with
anti-infective and waterproofing properties.
-
The average fetus at
28 weeks is 14.9 inches (37.9 cm)
long and weighs 2.7 pounds (1210
grams) .
-
Survival out of the womb at this age would be expected to be
~94% [21]
|
Gestational Age 29 to 31
weeks (6.6
months to 7.1 months)
.
Fetal Age 27 to 29 weeks |
|
-
The average fetus at
29 weeks is 15.4 inches (39.2 cm) long and
weighs 3 pounds (1379 grams) .
-
The average fetus at
30 weeks is 16 inches (40.5 cm)
long and weighs 3.4 pounds (1559
grams) .
-
The average fetus at
31 weeks is 16.5 inches (41.8 cm)
long and weighs 3.9 pounds (1751
grams) .
|
Gestational Age 32 to 33
weeks (7.4
to 7.6 months)
.
Fetal Age 30 to 31 weeks |
|
The fetus is forming muscle
and storing body fat. If the fetus is a boy, his testicles are
descending.
-
The average fetus at
32 weeks is 16.9 inches (43 cm)
long and weighs 4.3 pounds (1953
grams) .
-
The average fetus at
33 weeks is 17.3 inches (44 cm)
long and weighs 4.8 pounds (2162
grams) .
-
T he distal femoral epiphysis
ossification center
can usually be seen
in 72 % of fetuses at 33 weeks
[13,14]
|
Gestational Age 34 to 36
weeks (7.8
to 8.3 months)
.
Fetal Age 32 to 34 weeks |
|
The fetus is now considered to
be late preterm
-
The average 34 week fetus is 17.8
inches (45.2 cm) long and weighs 5.2 pounds
(2377 grams)
-
The average 35 week fetus is 18.2 inches
(46.3 cm) long and weighs 5.7 pounds (2595
grams)
- The proximal tibial epiphysis ossification
center may be seen in 35 % of fetuses at 35 weeks [13,14]
-
The average 36 week fetus is 18.6 inches
(47.3 cm) long and weighs 6.2 pounds (2813
grams)
|
Gestational Age 37 to 38
weeks
( 8.5 to 8.7 months)
.
Fetal Age 35 to 36 weeks |
|
The fetus is now considered to
be early term
-
The average 37 week fetus is 19. inches ( 48.3 cm) long and weighs 6.7 pounds (3028
grams)
-
The average 38 week fetus is 19.4 inches (49.2 cm) long and weighs 7.1 pounds (3236
grams)
- The proximal humeral epiphysis ossification center
may be seen at 38 weeks [15]
|
Gestational Age 39 to 41
weeks (9
to 9.4 months)
.
Fetal Age 37 to 39 weeks |
|
The fetus is now full term.
-
The average 39 week fetus is 19.7 inches (50.1 cm) long and weighs 7.6 pounds
(3435 grams)
-
The average 40 week fetus is 20.1 inches
(51 cm) long and weighs 8 pounds (3619 grams)
-
The average 41 week
fetus is 20.4 inches (51.8 cm) long
and weighs 8.3 pounds (3787 grams) .
|
Equations
Crown to Rump Length
LN (MA) =1.684969 + (.315646 CRL) - (.049306CRL^2) + (.004057
CRL^3) - (.000120456 CRL^4)
Hadlock FP et. al.,Fetal
crown-rump length: reevaluation of relation to menstrual age
(5-18 weeks) with high-resolution real-time US. Radiology.
1992 Feb;182(2):501-5.PMID: 1732970<br>
Crown to Heel
Length (cm)= -0.0219^2 * Gestational age (weeks) + 2.5764* Gestational age (weeks) -17.059
Equation extrapolated from FIGURE 2 in Fenton
TR. A new growth chart for preterm babies: Babson and Benda's
chart updated with recent data and a new format. BMC Pediatr.
2003 Dec 16;3:13. doi: 10.1186/1471-2431-3-13. PMID: 14678563;
PMCID: PMC324406.
Weight
ln weight (g)=0.578
+ 0.332*MA -.00354*MA^2
Hadlock FP, et al., In utero
analysis of fetal growth: a sonographic weight
standard.Radiology. 1991 Oct;181(1):129-33.PMID: 1887021
Reviewed 1/2/2023
References
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1732970
2. Vintzileos AM, Campbell WA, Neckles S, Pike CL, Nochimson DJ.The
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[Accessed June 2021]
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