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THE INFORMATION IN THE OBPHARMTM
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UPDATE WHICH AFFECT THE ACCURACY AND AVAILABILITY OF THE INFORMATION PRESENTED.
The
National Institute for Health and Care Excellence recommends pregnant women be offered
"tenofovir disoproxil to women with HBV DNA greater than 10^7 IU/ml in
the third trimester to reduce the risk of transmission of HBV to the baby"
[1]
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases,
have been reported with the use of nucleoside analogues alone or in combination
with antiretrovirals
Severe acute exacerbations of hepatitis B have been reported in patients who
have discontinued anti-hepatitis B therapy.
Tenofovir disoproxil fumarate,
TDF; Viread®
Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of
tenofovir. Tenofovir is a nucleotide analog HIV-1 reverse transcriptase inhibitor and an HBV
reverse transcriptase inhibitor. M.W. 635.5
- Chronic hepatitis B
in adults and pediatric patients 12 years of age and older (35 kg or more):
300 mg once daily
taken orally without regard to food.
Adjust dose in patients with renal impairment
(150, 200, 250 and 300 mg tablets, 40 mg per 1 g of oral powder)
Breastfeeding
Viread package insert. Gilead Sciences, Inc. 6/2015
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=33fd6418-fbdc-42ca-a50d-ce2a476a5418
Accessed 11/8/2015
PubChem
Lamivudine (3TC)
Synthetic nucleoside analogue. Hepatitis B Virus
Nucleoside Analog Reverse Transcriptase Inhibitor and Human Immunodeficiency
Virus Nucleoside Analog Reverse Transcriptase Inhibitor. M.W. 229.3
- Treatment
of chronic hepatitis B virus (HBV) infection associated with evidence of
hepatitis B viral replication and active liver .
100 mg once daily taken orally
Adjust dose in patients with renal impairment
(100 mg , bottles of 60 tablets)
Breastfeeding
REFERENCES
Lamivudine Tablets (HBV) Apotex Corp.12/2013
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=87095352-c088-74b1-7be0-d3e293a90611.
Accessed 12/18/2015
PubChem
Telbivudine (LdT)
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. M.W. 242.2
-
Treatment of chronic hepatitis B in adult patients with evidence of viral
replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Adults and Adolescents (16 years of age and older)
600 mg once daily taken orally with or without food
Adjust dose in patients with renal impairment
(600 mg tablets, oral solution contains 100 mg of telbivudine per 5 milliliters.)
Tyzek package insert Novartis Pharmaceuticals Corporation 1/2013.
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0664309d-1342-4a63-ba5f-4b899cdf3bec
Accessed 12/18/2015
PubChem
References
1.
Hepatitis B (chronic) : diagnosis and management
NICE guidelines [CG165] Published date: June 2013
National Institute for Health and Care Excellence.
http://www.nice.org.uk/guidance/cg165/chapter/1-recommendations#antiviral-treatment.
Accessed 11/8/2015
2.
European Association For The Study Of The Liver.EASL clinical practice
guidelines: Management of chronic hepatitis B virus infection. J Hepatol. 2012
Jul;57(1):167-85. PMID: 22436845
3. Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the
prevention of vertical transmission of HBV infection.
Celen MK, Mert D, Ay M, Dal T, et. al., .World J Gastroenterol. 2013 Dec 28;19(48):9377-82. doi:
10.3748/wjg.v19.i48.9377.PMID:24409065
4. van Zonneveld M,et al., Lamivudine treatment during pregnancy to
prevent perinatal transmission of hepatitis B virus infection. J Viral Hepat.
2003 Jul;10(4):294-7. PMID: PMID:12823596
5. Han L, et al., A meta-analysis of lamivudine for interruption of
mother-to-child transmission of hepatitis B virus. World J Gastroenterol.
2011 Oct 14;17(38):4321-33. doi: 10.3748/wjg.v17.i38.4321.
PMID:22090789
6. Han GR, et al., A prospective and open-label study for the efficacy and
safety of telbivudine in pregnancy for the prevention of perinatal
transmission of hepatitis B virus infection. J Hepatol. 2011
Dec;55(6):1215-21. doi: 10.1016/j.jhep.2011.02.032. 2011 Apr 15
PMID:21703206
7. Zhang H, et. al., Telbivudine or lamivudine use in late pregnancy safely
reduces perinatal transmission of hepatitis B virus in real-life practice.
Hepatology. 2014 Aug;60(2):468-76. PMID: 25187919
8 Hu YH, et. al., Tenofovir rescue therapy in pregnant females with chronic
hepatitis B.World J Gastroenterol. 2015 Feb 28;21(8):2504-9. doi:
10.3748/wjg.v21.i8.2504. PMID: 25741161
9. Celen MK,et. al., Efficacy and safety of tenofovir disoproxil fumarate
in pregnancy for the prevention of vertical transmission of HBV infection.
World J Gastroenterol. 2013 Dec 28;19(48):9377-82. doi:
10.3748/wjg.v19.i48.9377. PMID: 24409065
10. Chen HL, et. al., Taiwan Study Group for the Prevention of
Mother-to-Infant Transmission of HBV (PreMIT Study); Taiwan Study Group for
the Prevention of Mother-to-Infant Transmission of HBV PreMIT Study.Efficacy
of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant
transmission of hepatitis B virus.Hepatology. 2015 Aug;62(2):375-86. doi:
10.1002/hep.27837. Epub 2015 May 13.PMID: 25851052
11. Greenup AJ, et. al., Efficacy and safety of tenofovir disoproxil
fumarate in pregnancy to prevent perinatal transmission of hepatitis B
virus.J Hepatol. 2014 Sep;61(3):502-7. doi: 10.1016/j.jhep.2014.04.038.PMID:
24801414
12. Wong F, et. al., Hepatitis B in pregnancy: a concise review of neonatal
vertical transmission and antiviral prophylaxis. Ann Hepatol. 2014
Mar-Apr;13(2):187-95. PMID: 24552860
13.Lamberth JR,et. al., Chronic hepatitis B infection in pregnancy.World J
Hepatol. 2015 May 28;7(9):1233-7. doi: 10.4254/wjh.v7.i9.1233.PMID: 26019737
14.Ehrhardt S, et. al.,Breastfeeding while taking lamivudine or tenofovir
disoproxil fumarate: a review of the evidence.Clin Infect Dis. 2015 Jan
15;60(2):275-8. doi: 10.1093/cid/ciu798. Epub 2014 Oct 13. PMID: 25313254
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