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THE INFORMATION IN THE OBPHARMM
IS INTENDED SOLELY FOR USE BY THE MEDICAL PROFESSION. IT IS NOT INTENDED FOR LAY PERSONS.
FOCUS INFORMATION TECHNOLOGY, INC. DOES NOT ASSUME ANY RESPONSIBILITY FOR ANY ASPECT OF
HEALTHCARE ADMINISTERED WITH THE AID OF THIS CONTENT. THE PRESCRIBING PHYSICIAN
MUST BE FAMILIAR WITH THE FULL PRODUCT LABELING AS PROVIDED BY THE MANUFACTURER AND RELEVANT MEDICAL LITERATURE PRIOR TO USING THE
OBPHARM TM
.CHANGES MAY OCCUR SINCE THE LAST
UPDATE WHICH AFFECT THE ACCURACY AND AVAILABILITY OF THE INFORMATION PRESENTED
Acyclovir , Zovirax®
Nucleoside Analog DNA Polymerase Inhibitor. M.W. 225.2.
- Acute Treatment of Herpes Zoster (Shingles) Adults
800 mg every 4 hours orally, 5 times daily for 7 to 10 days.
- Acute Treatment of Varicella (Chickenpox) Adults
800 mg orally 4 times daily for 5 days.
Severe Disease Adults (complicated disease -e.g. disseminated infection, pneumonitis, hepatitis, meningitis or encephalitis) [1]
5–10 mg/kg IV every 8 hours for 2–7 days or until clinical improvement
is observed, followed by oral antiviral therapy to complete at least 10 days of
total therapy HSV encephalitis requires 21 days of intravenous therapy.
Adjust dose in patients with acute or chronic renal impairment
(200, 400, 800 mg tablets; 200 mg /5 mL suspension -Bottle of 1 pint -473 mL)
For full prescribing information see Acyclovir package insert. Teva Pharmaceuticals USA Inc 1/2015
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f0d8278e-f521-451b-9093-16571eccd284
Breastfeeding : Even
with the highest maternal dosages, the dosage of acyclovir in milk is only about
1% of a typical infant dosage and would not be expected to cause any adverse
effects in breastfed infants. LACTMED 12/12/2015
Valacyclovir (Valtrex®)
Nucleoside Analog DNA Polymerase Inhibitor M.W. 324.3
.After oral administration, valacyclovir hydrochloride is rapidly absorbed from
the gastrointestinal tract and nearly completely converted to acyclovir
- Acute Treatment of Herpes Zoster (Shingles) Adults:
1
gram orally 3 times daily for 7 days. Therapy should be initiated at the earliest
sign or symptom of herpes zoster .
Adjust dose in patients with acute or chronic renal impairment
(500 mg, 1 gram caplets)
For full prescribing information see Valtrex package insert GlaxoSmithKline 12/2013.
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f8e0d8f8-cb73-4206-a484-88f5c4fbd719
Breastfeeding
Varicella zoster immune globulin (VariZIG) [2]
-
Indicated for for post-exposure prophylaxis of varicella in
high risk individuals (pregnant women without evidence of immunity) within 10 days (ideally within 4 days) of chickenpox
(varicella zoster virus) exposure . Adults.
125 IU/10 kg of body weight intramuscularly into the
deltoid muscle or the anterolateral aspect of the upper thigh, up to a maximum
of 625 IU (five vials).
-
The intramuscular dose should be divided and administered in
two sites, dependent on patient size.
-
Do not exceed 3 mL per injection site
( Single-use vial of 125
IU in 1.2 mL)
For full prescribing information see VARIZIG® package insert Cangene BioPharma 8/2015.
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac96a331-e2ff-4839-a4d5-fda3d858c969
VariZIG can be ordered from the exclusive U.S. distributor,
FFF Enterprises (Temecula, California) (telephone, 800-843-7477; online at
http://www.fffenterprises.com
)
REFERENCES 1..
Workowski KA, Bolan GA; Centers for Disease Control
and Prevention.Sexually transmitted diseases treatment guidelines, 2015.
MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137. PMID: 26042815
2.
Updated recommendations for use of VariZIG--United States, 2013.
Centers for Disease Control and Prevention (CDC).
MMWR Morb Mortal Wkly Rep. 2013 Jul 19;62(28):574-6. PMID: 23863705
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