Fluticasone propionate ( CutivateŽ)  0.05% cream
Topical Anti-inflammatory Corticosteroid

• Indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

     Apply a thin film of  0.05% cream to the affected skin areas twice daily. Rub in gently.

(15 and 60 g tubes)

The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women. Fluticasone propionate ointment and cream should be used during pregnancy only if the potential benefit to the woman justifies the potential risk to the fetus.

Clobetasol propionate ( TemovateŽ) 0.05% Cream or ointment
Topical Anti-inflammatory Corticosteroid

• Indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

     Apply a thin film of  0.05% cream or ointment  to the affected skin areas twice daily. Rub in gently.

Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

Temovate Cream and Ointment should not be used with occlusive dressings, in the treatment of rosacea or perioral dermatitis, or on the face, groin, or axillae.

( 30, 45, 60 g tubes)
 

Clobetasol propionate was teratogenic in mice and rabbits when applied topically. Abnormalities seen included cleft palate, cranioschisis, and other skeletal abnormalities.There are no adequate and well-controlled studies of the teratogenic potential of clobetasol propionate in pregnant women. TEMOVATE Cream and Ointment should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk.

REFERENCES;

1. Scheinfeld N. Pruritic urticarial papules and plaques of pregnancy wholly abated with one week twice daily application of fluticasone propionate lotion: a case report and review of the literature.Dermatol Online J. 2008 Nov 15;14(11):4. PMID: 19094842

2. Cutivate. GlaxoSmithKline Consumer Healthcare Inc. 2030 Bristo Circlel, Oakville, Ontario. Date of Preparation: July 26, 2004. FAD Rev date: 4/16/2002

3. Temovate Glaxo Wellcome Inc. Research Triangle Park, NC 27709. July 2000. FDA Rev date: 4/2/2003