Some causes of elevated alkaline phosphatase include
Paget disease, healing fractures, acromegaly, osteogenic sarcoma, liver or bone
metastases, leukemia, myelofibrosis, rickets, osteomalacia, hypervitaminosis D ,
cholestasis of pregnancy, biliary obstruction, hyperthyroidism, infiltrative
liver diseases (eg, sarcoid, TB, amyloidosis, abscess), cirrhosis, and myeloma.
Low levels may be found in hypophosphatasia, and less commonly in hypothyroidism
.
References:
Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory
studies: a reference table for clinicians. Obstet Gynecol. 2009
Dec;114(6):1326-31. PMID:19935037
Wallach, J. Interpretation
of Diagnostic Tests, Eighth ed. Lippincott Williams & Wilkins, 2007 Fischbach FT, Dunning MB III, eds.
A Manual of Laboratory and Diagnostic Tests, 7th ed. Philadelphia,
Lippincott Williams and Wilkins,2004