Reference Values During Pregnancy

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Bilirubin , total (serum)

   Units Nonpregnant Adult First Trimester Second Trimester Third Trimester
mg/dL 0.3 - 1.3
0.1 - 0.4
0.1 - 0.8 0.1 - 1.1
μmol/L 5.1 - 22.2 1.7 -  6.8 1.7 -  13.7 1.7 -  18.8

Some causes of elevated total bilirubin include hepatitis, cholangitis, biliary obstruction, mononucleosis , Dubin-Johnson syndrome, Gilbert disease, prolonged fasting, pernicious anemia, cirrhosis, neoplasia, alcoholism , hemolytic anemias, hematoma, blood transfusion of several units over a short time, pulmonary embolism, and congestive heart failure. In additon numerous drugs including phenytoin, phenothiazines, erythromycin, penicillin, sulfonamides, oral contraceptives, halothane, aminosalicylic acid, isoniazid, methyldopa, and indomethacin may cause elevated total bilirubin.


Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol. 2009 Dec;114(6):1326-31. PMID:19935037
Wallach, J. Interpretation of Diagnostic Tests, Eighth ed. Lippincott Williams & Wilkins, 2007 Fischbach FT, Dunning MB III, eds. A Manual of Laboratory and Diagnostic Tests, 7th ed. Philadelphia, Lippincott Williams and Wilkins,2004


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