An inversion in which
the breakpoints occur on both arms of a chromosome. The inverted segment
includes the centromere
the constricted portion of the chromosome).
Inversion of chromosome 3 or 8 has been associated with an increased
risk for abnormal offspring . Pericentric inversion of chromosome 9 appears to be a normal
variant in humans, and occurs in approximately one percent of the
population. Inversion of chromosome 9 does not appear to
be associated with an increased risk of miscarriage or abnormal offspring.
Pericentric inversion of the y chromosome is usually a familial variant
of no known clinical significance occurring in 1 in 1000 males. A
chromosome analysis of the father's blood may be performed to
determine if this Y chromosome is inherited ( 5 mL in a green top sodium