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Telangiectasias
Small
enlarged blood vessels near the surface of the skin 1 to 3 mm in width and
several mm to centimeters in length.
Teratogen
Anything that can cause a birth defect such as a maternal
condition (diabetes, PKU) , a drug (alcohol), a medication (valproic acid,
isotretinoin) , an infectious agent (toxoplasmosis, cytomegalovirus) or a
physical agent (ionizing radiation).
Testicle (Testis)
Either of the two male reproductive organ found in the pouch (scrotum) below
the penis. The testicles produce sperm and sex hormones.
Testosterone
A steroid hormone produced by the Leydig cells of the
testicles (and to a lesser extent the ovaries and adrenal glands) that promotes
the development of secondary male sexual characteristics.
Normal Values
Male: 10 - 35 nmol/L (3 - 10 ng/mL)
Female: Less than 3.5 nmol/L ( < 1 ng/mL)
Prepubertal boys and girls: 0.17 - 0.7 nmol/L (0.05 -0.2 ng/mL)
Tetralogy of Fallot
A complex congenital heart defect named after the French physician Louis Arthur
Fallot who made the first complete description of this heart disease. TOF is
thought to be caused by malalignment of the conal septum during early
development. Although TOF has been associated with chromosome 22 deletions and
some chromosomal abnormalities most cases of TOF have no known cause.
TOF has the following four features:
1) A ventricular septal defect (VSD)
2) Pulmonary stenosis causing obstruction of blood flow from the right ventricle
to the lungs
3) An overriding aorta -the aorta lies directly over the VSD between the left
and right ventricles.
4) Right ventricle hypertrophy due resistance to blood flow from the right
ventricle.
As a result of these features, oxygen-poor blood from the right ventricle flows
preferentially across the VSD directly into the aorta instead of into the
pulmonary artery to the lungs. This is known as a right-to-left shunt and causes
the infant to appear cyanotic (blue).
After delivery a Blalock-Thomas-Taussig shunt may be performed on infants with
severe variants such as TOF with pulmonary atresia (pseudotruncus arteriosus).
Otherwise surgery to relieve the right ventricular outflow tract stenosis (by
resection of muscle), and repair the VSD is usually done in infants at 1 year of
age or younger. Pulmonary valve replacement is often required as an adolescent
or young adult.
Differential diagnosis includes pulmonary atresia with VSD, double outlet right
ventricle (DORV), and perimembranous VSD.
See Also
Thalassemia
A group of inherited blood disorders characterized by moderate to severe
anemia. Thalassemias are caused by defects in the genes that control production
of globins, the building blocks of hemoglobin (the oxygen carrying molecule in
red blood cells).
The two main types of thalassemia are
alpha-thalassemia
and beta-thalassemia . |
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Hemoglobin |
Thrombocytopenia
A lower than normal number (count) of platelets in the blood. Platelets are
cell fragments in the blood that help to form blood clots.
150,000 to 450,000 platelets per microliter (x 10–6/Liter)
Persons with low platelet numbers may experience nosebleeds, gum bleeding ,
bruises and small red pinpoints on the skin (petechiae). Rarely persons will
experience bleeding into the urine, gastrointestinal tract, or into the head
with very low platelet numbers.
Common causes of thrombocytopenia during pregnancy include:
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Systemic lupus Erythematosus, antiphospholipid syndrome, human
immunodeficiency virus (HIV) infection , B12 or folate deficiency,
hyperthyroidism, massive transfusion, prosthetic heart valves, thrombotic
Thrombocytopenic Purpura (TTP), sepsis , disseminated intravascular coagulation
(DIC) , hypersplenism, hemolytic uremic syndrome, hereditary thrombocytopenias,
alcoholism, leukemia, aplastic anemia
Thrush (Candidiasis)
A yeast (Candida) infection of the tongue , mouth , and
throat characterized by white patches and ulcers. Thrush is usually seen in
infants , but occurs with increased frequency in adults with diabetes or HIV.
Titer
The concentration of an antibody in the blood.
The titer is measured by diluting a sample until the antibody is no longer
detectable.
The result is given as the reciprocal (inverse) of the last dilution giving a
measurable effect.
Example:
-
A blood sample (tube 1) has been diluted by
1/2 to produce tube 2, tube 2 was
diluted by 1/2 to produce tube 3
and so forth.
-
A substance was added to each tube to
detect antibody.
-
The 4th tube is the last dilution at which
the antibody is detected, and it is 1/8 th the
strength of the original sample.
-
The titer of the antibody is therefore
8.
1
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2
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3
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4
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5
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6
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1:1
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1:2
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1:4
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1:8
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1:16
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1:32
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Tocolytic
A substance that decreases uterine contractions.
Total iron-binding capacity (TIBC)
A measurement of the amount of iron that can potentially be bound by transferrin.
- If the iron stores in the body are low, fewer sites on the transferrin
molecules will be filled by iron, and the TIBC will be higher. If the amount
of transferrin is increased the TIBC will also be increased.
- If the iron stores in the body are very high the or transferrin is
decreased then the TIBC will be low because most of the binding sites
are filled. A low TIBC may be seen in hemochromatosis, sideroblastic anemia,
and liver disease.
Toxemia (Preeclampsia)
Toxoplasmosis
An illness caused by the parasite,
Toxoplasma gondii. Toxoplasma gondii is found in raw and undercooked meat;
unwashed fruits and vegetables; dirty cat-litter boxes; and outdoor places where
cat feces can be found.Fetal infection can occur via transplacental
transmission.
http://www.cdc.gov/toxoplasmosis/
Transferrin
The protein found in blood that carries iron. The liver produces transferrin,
and increases its production of transferrin in response to iron deficiency and
pregnancy.
Transferrin saturation (%)
SEE
Percent transferrin saturation (TSAT)
Transposition of the great arteries (TGA, Transposition of the Great
Vessels, TGV )
A birth defect of the heart in which the the aorta and
the pulmonary artery are switched (transposed). The aorta arises from the right
ventricle instead of from the left ventricle, and the pulmonary artery arises
from the left ventricle instead of arising from the right ventricle. In
transposition of the great arteries the blood from the body enters the right
side of the heart and flows into the aorta back to the body without receiving
oxygen from the lungs.
While in the uterus the fetus is able to maintain adequate delivery of oxygen
to the body because the formen ovale allows mixing of blood between the right
and left atrium and the ductus arteriosus allows mixing of the blood between the
pulmonary artery and the aorta. After delivery the baby
will become blue due to lack of oxygen if these structures are not kept open.
The ductus may be kept open using drugs,and the
foramen ovale can be enlarged with a catheter procedure which is performed in
the first few days of life. An "Arterial Switch Operation"
carried out in the first week or two of life corrects the primary abnormality.
The small coronary arteries, which feed the heart muscle are transferred
as well.
T-sign
On ultrasound examination the junction of two amniotic sacs forms a 90 degree
angle with the placenta, a T-shaped junction. There is no placental tissue
extending between the amniotic membranes. The T-sign strongly indicates that
there is a single placenta (monochorionic).
Twin peak sign, Lambda sign
On ultrasound examination the presence of a triangular projection of placental
tissue extending between two amniotic sacs. The twin peak sign strongly
indicates that there are two separate placentas (dichorionic).
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