Monthly Archives: March 2015

Governments can prevent tragic death toll of mothers, babies

Governments could substantially reduce the tragic death toll of infants and mothers by making postnatal care services more accessible -- especially to impoverished and poorly educated women in rural areas, according to a WHO study. Postnatal care for mothers and babies includes, for example, keeping them in the facility for 24 hours before discharge or visiting them as soon as possible after a home delivery; repeated assessments of mother and newborn babies allows to identify problems early and manage them promptly. Data from 15 low and middle-income countries and territories found that many mothers are not using postnatal services because they are not easily accessible, too expensive, or because mothers do not know when they and their babies need them.

New clues to why poor nutrition in the womb leads to obesity later in life

Babies receiving poor nutrition in the womb tend to be smaller at birth, which has been linked to the development of obesity and other health problems later in life. Researchers continue to discover other consequences related to undernutrition during pregnancy. A new study examines how poor fetal nutrition affects protein expression in the fat tissue of adult rats, revealing key differences between males and females.

Glyburide associated with more risk of adverse events than insulin in newborns

The medication glyburide, which has been increasingly used to treat gestational diabetes in pregnant women, was associated with higher risk for newborns to be admitted to a neonatal intensive care unit, have respiratory distress, hypoglycemia (low blood glucose), birth injury and be large for gestational age compared with infants born to women treated with insulin, according to a new article.

Comparative efficacy and safety of oral antidiabetic drugs in management of gestational diabetes

Meta-analysis shows that compared with insulin glyburide was associated with higher neonatal birth weight , increased incidence of neonatal hypoglycemia , increased incidence of macrosomia .

http://press.endocrine.org/doi/abs/10.1210/jc.2014-4403?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Jiang YF, et. al., Comparative efficacy and safety of oral antidiabetic drugs in management of gestational diabetes: network meta-analysis of randomized controlled trials.
J Clin Endocrinol Metab. 2015 Mar 24:jc20144403. [Epub ahead of print] PMID: 25803270

Study provides evidence against the fetal origins of cancer, cardiovascular disease

A study evaluated the relationship between nutritional conditions in early life and adult health, and found that famine exposure during the first pregnancy trimester was associated with increases in mortality from causes other than cancer or cardiovascular disease. This is the first study to quantify the possible long-term effects of nutrition deprivation at different stages of pregnancy and long-term mortality.