Pregnant women at risk for developing preeclampsia should take low-dose aspirin

Pregnant women  at risk for developing preeclampsia should take low-dose aspirin daily to reduce their chance of developing the disorder according to new recommendations by the U.S. Preventive Services Task Force (USPSTF).

The USPSTF recommends low-dose aspirin (81 mg/day) preventive medication after 12 weeks’ gestation in women who are at high risk for preeclampsia.

Women at high risk include:

  • Prior preeclampsia, especially when accompanied by an adverse outcome
  • Multiple gestation pregnancy
  • Chronic hypertension
  • Type 1 or 2 diabetes
  • Renal disease
  • Autoimmune disease (i.e., systemic lupus erythematous, antiphospholipid syndrome)

In addition The U.S. Preventive Services Task Force (USPSTF)  recommends women with more than one moderate risk factor for pre-eclampsia should to take 81 mg of aspirin daily after 12 weeks of gestation

Moderate risk factors include:

  • Nulliparity (first pregnancy)
  • Obesity (i.e., body mass index >30 kg/m2)
  • Family history of preeclampsia (i.e., mother, sister)
  • Sociodemographic characteristics (i.e., African American race, low socioeconomic status)
  • Age ≥35 years
  • Personal history factors (e.g., low birth weight or small for gestational age, previous adverse pregnancy outcome, >10-year pregnancy interval)

The USPSTF recommendations are similar to recommendation given by the National Institute for Health and Clinical Excellence (NICE) in previous years.

The USPSTF Draft Recommendation Statement is available at:

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